Paraneoplastic syndromes of the CNS.

By J. Dalmau, M. Rosenfeld. Lancet Neurology, 2008

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The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. (2012, neutral): “The associated syndrome is characterized by prevalent psychiatric symptoms and behavioral changes that are often accompanied by seizures, dyskinesias, language dysfunctions, and, in many cases, autonomic instability and hypoventilation [5, 6].”
AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location (2009, neutral): “ble explanation for these outcomes is that the accompanying immune responses, particularly if associated with cytotoxic T-cell mechanisms, are more difficult to treat, or that the neuronal dysfunction is less reversible than that caused by the anti-GluR1/2 immune response, which appears to be direct”
Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. (2012, background): “…however, that the most important determinant of the underlying immunopathogenesis and responsiveness to immunosuppression is the antibody status of the affected individual, which may determine the response to treatment (Dalmau and Rosenfeld, 2008; Graus et al., 2010; Vincent et al., 2010).”