Genome-wide analysis identifies 12 loci influencing human reproductive behavior
By Nicola Barban, R. Jansen, R. Vlaming, Ahmad Vaez, Jornt J. Mandemakers, Felix C. Tropf, Xia Shen, James F. Wilson, Daniel Chasman, I. Nolte and 244 more. Nature Genetics, 2016
129 citations recorded by the source corpus.
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Subfields: Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/b0983ed85746c635a0f85961654d83658fd6e991
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Citations in the corpus
- The nature of nurture: Effects of parental genotypes (2017, background): “Notably, for EA, AGFC, HT, and HLTH, the adjusted estimate remains highly significant ( P 0.005), and the ratio of the adjusted versus unadjusted estimate is, respectively, 47.6%, 63.0% , 80.3%, and 68.6% .”
- Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits (2018, unknown): “Genomic SEM (WLS) 118 69 (5) 38 1 19 20 1.”