Astrocytic Purinergic Signaling Coordinates Synaptic Networks

By O. Pascual, Kristen B. Casper, Cathryn L. Kubera, Jing Zhang, R. Revilla-Sánchez, J. Sul, H. Takano, S. Moss, K. McCarthy, Philip Haydon. Science, 2005

1,292 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/b05967981f1aadfd210ae4515a8d129a09346ab8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Maiken Nedergaard
2. Philip Haydon
3. Andrea Volterra
4. Giorgio Carmignoto
5. Michael M. Halassa
6. S. Goldman
7. Tommaso Fellin
8. N. Oberheim

In Neurology

1. Maiken Nedergaard
2. Philip Haydon
3. S. Goldman
4. Michael M. Halassa
5. Andrea Volterra
6. Giorgio Carmignoto
7. B. Barres
8. B. Philpot

In Physiology

1. Maiken Nedergaard
2. B. Barres
3. Philip Haydon
4. Andrea Volterra
5. Giorgio Carmignoto
6. S. Goldman
7. Alexei Verkhratsky

Citations in the corpus

• Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo (2006, background): “In addition to perpetuating astrocytic Ca 2+ waves, ATP following hydrolysis to adenosine controls hippocampal network activit”
• Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation (2007, background): “…and inhibitory synaptic transmission and plasticity (Kang et al., 1998; Beattie et al., 2002; Yang et al., 2003; Fiacco and McCarthy, 2004; Pascual et al., 2005), as well as synaptogenesis and neuronal wiring (Collazos-Castro and NietoSampedro, 2001; Fasen et al., 2003; Ullian et al.,…”
• Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “Since the release of ATP from astrocytes exhibits sensitivity to tetanus toxin and is blocked by expression of a cytosolic SNARE domain (164), an exocytic mechanism may underlie the release of this nucleotide.”
• The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “ATP release by astrocytes regulates CNS synaptic transmission in vivo (Pascual et al., 2005), and it is thus likely that this glial release in vivo occurs from secretory lysosomes.”
• Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice (2013, background): “Astrocytes release ATP, which, after degradation to adenosine by extracellular ectonucleotidases, can suppress both basal synaptic transmission and activitydependent increases in synaptic strength (Pascual et al., 2005; Zhang et al., 2003).”