Bone Marrow Edema and Its Relation to Progression of Knee Osteoarthritis

By David T Felson, S. McLaughlin, J. Goggins, M. Lavalley, M. Gale, S. Totterman, Wei Li, C. Hill, D. Gale. Annals of Internal Medicine, 2003

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Epidemiology of Osteoarthritis (2010, neutral): “A randomized, placebo-controlled clinical trial of vitamin D is currently underway to examine whether this vitamin can affect knee symptoms and cartilage loss measured on MRI in established knee OA.”
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes (2013, background): “Some histopathological changes in the subchondral bone have also been detected, including microdamage, bone marrow edema-like lesions and bone cysts [7-9].”
Why is Osteoarthritis an Age-Related Disease? (2010, background): “These lesions are associated with knee pain, limb mal-alignment, and meniscal derangement, and may predict OA progression [34–36].”
Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations (2013, background): “The mainstay of synovial imaging has been MRI, with early studies demonstrating the presence of bone marrow edema along the medial or lateral knee predicting progression of OA in their respective compartments [Felson et al. 2003].”
The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries (2007, background): “Current work suggests that the subchondral bone and synovium are responsible for nociceptive stimuli and that peripheral neuronal sensitization is an important feature in OA pain.(18,29,55,111,173) Central pain sensitization may also occur, and psychosocial factors are important determinants of pain”