Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.

By S. Prakash, Robert E. Johnson, L. Prakash. Annual Review of Biochemistry, 2005

1,018 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b025806a3bd8ae05759ad7efc51b9d52ff10a560

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Citations in the corpus

• Regulation of homologous recombination in eukaryotes (2010, background): “TLS is favored by mono-ubiquitination of proliferating cell nuclear antigen (PCNA) on K164 by the Rad6-Rad18 E2-E3 complex (Figure 2), which enhances the intrinsic affinity of Y-family TLS polymerases (Pol eta) for PCNA through their ubiquitin binding motifs (126).”
• Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. (2011, neutral): “However, besides DNA replication, PCNA functions are associated with other vital cellular processes such as chromatin remodelling, DNA repair, sister-chromatid cohesion and cell cycle control (Maga and Hubscher, 2003).”
• Loss of DNA Polymerase ζ Causes Chromosomal Instability in Mammalian Cells (2006, background): “The der(19)ins(3;19) and i(3)+t(3;19) abnormalities are possible products of a reciprocal translocation event.”
• Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells (2008, background): “Most ROSinduced oxidized base lesions and abasic (AP) sites if left alone could be replicated by replicative or DNA translesion synthesis (TLS) polymerases [4,5].”
• A novel function of DNA polymerase ζ regulated by PCNA (2006, background): “The last several years have seen the discovery of DNA polymerases that have the ability to bypass lesions in template DNA that block replicative DNA polymerases ( Prakash et al, 2005 ).”
• Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link (2015, neutral): “Each vertebrate TLS polymerase is thought to bypass a particular class of lesion (Prakash et al , 2005), and lesion bypass often requires the sequential action of two different TLS polyme-rases.”