The cortical column: a structure without a function

By J. Horton, D. L. Adams. Philosophical Transactions of the Royal Society B: Biological Sciences, 2005

605 citations recorded by the source corpus.

Subfields: Political Science and International Relations, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/afca91e167d89fe9292904d8df9023ff76507ea9

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Citations in the corpus

The use and abuse of large-scale brain models. (2014, positive): “The model is focused on simulating cortical columns, hypothesized cylindrical groups of approximately 100,000 neurons that make up the cerebral cortex of mammals [11,12], but see also [13].”
Reading hidden intentions in the human brain. (2007, background): “Such a columnar architecture has been highly debated as a general principle of cortical organization [40, 41] and has been claimed for the prefrontal cortex [42].”
The atoms of neural computation (2014, background): “Likewise, canonical structural features such as ocular dominance columns appear in some parts of cortex but not in most others, and are present in some closely-related species but not in others (Horton & Adams, 2005).”
How the brain might work: a hierarchical and temporal model for learning and recognition (2008, background): “organization is generally accepted, its function is still debated [52].”
Cultural recycling of cortical maps. (2007, neutral): “Even in wellcharacterized cases such as ocular dominance columns, their functional role, if any, remains debated (Horton and Adams, 2005).”
On reverse engineering in the cognitive and brain sciences (2012, background): “With other words, it is not feasible for specific functions to be mapped to structurally bounded neuronal structures [20, 39, 40, 41].”
Neuroimaging: Decoding mental states from brain activity in humans (2006, neutral): “, even if it is currently unclear to what degree it is a principally necessary featur”
Canonical microcircuits for predictive coding. (2012, positive): “Minicolumns were originally proposed as elementary units of cortex by Lorente de No (1949) and appear to reflect the migration of cells from the ventricular zone to the cortical sheet during fetal development (reviewed in Horton and Adams, 2005).”
How Prediction Errors Shape Perception, Attention, and Motivation (2012, methodology): “In short, feedback “prediction units” (e.g., deep layers in hierarchically higher visual areas, CA3, prefrontal cortex) set an activity pattern that is integrated with feedforward inputs in “PE units” (e.g., granular layer in hierarchically lower visual areas, CA1, VTA), to reflect the difference…”
Imaging retinotopic maps in the human brain (2010, background): “An interesting and open question is whether the presence of a regular spatial structure, such as a map, is essential for proper visual function (Horton & Adams, 2005).”
Can structure predict function in the human brain? (2010, neutral): “of cortical computation that is shared across many species (Horton and Adams, 2005).”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “Since hind-limb somatosensory cortex, unlike barrel cortex, has no anatomically defined horizontal columnar organization (Horton and Adams, 2005; Markram, 2008), we chose to define the radius of the microcircuit by placing reconstructed neurons in a cylindrical volume and determining the minimal rad”