An Immune Atlas of Clear Cell Renal Cell Carcinoma
By Stéphane Chevrier, Jacob H. Levine, V. R. T. Zanotelli, K. Silina, D. Schulz, M. Bacac, Carola H. Ries, L. Ailles, M. Jewett, H. Moch and 7 more. Cell, 2017
898 citations recorded by the source corpus.
Summary Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/afa0a59eb160d3bd251b7db028a6e00a1a43bd2a
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Citations in the corpus
- Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade (2017, neutral): “Examination of additional parameters, such as costimulatory molecules, may offer additional clarity by providing an even finer resolution catalog of T cell subsets, as in recent analyses of renal cell carcinoma (Chevrier et al., 2017).”
- Organoid modeling of the tumor immune microenvironment (2018, methodology): “These can be confounded by antibody specificity, tumor PD-L2 expression, PD-L1 expression on multiple TME cell types (Topalian et al., 2016), and significant false-positive and falsenegatives (Carbognin et al., 2015; Garon et al., 2015).”
- OMIP-044: 28-color immunophenotyping of the human dendritic cell compartment (2018, background): “Importantly, increasing evidence suggests that studying DC biology in the context of autoimmune diseases (9) as well as cancer progression might reveal novel approaches for therapeutic interventions (10,11).”