SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.

By C. Fertleman, M. Baker, K. Parker, Sarah Moffatt, F. Elmslie, B. Abrahamsen, J. Ostman, N. Klugbauer, J. Wood, R. Gardiner and 1 more. Neuron, 2006

742 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/af732a0b6cea16d7e7d2861d6dee77a26213407c

How researchers see this paper

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In Molecular Biology

1. Jie Zheng
2. M. Trudeau

In Physiology

1. Jie Zheng
2. M. Trudeau

Citations in the corpus

• Handbook of ion channels (2015, background): “Paroxysmal extreme pain disorder (PEPD) is a distinct syndrome associated with bouts of pain that is spontaneous or triggered by innocuous stimuli (53,54).”
• Cellular and Molecular Mechanisms of Pain (2009, neutral): “7 leads to hyperexcitability of the channel and are associated with two distinct pain disorders in humans, erythromelalgia and paroxysmal extreme pain disorder, both of which cause intense burning sensations (Estacion et al., 2008; Fertleman et al., 2006; Yang et al., 2004).”