Natural products to drugs: natural product-derived compounds in clinical trials.

By M. Butler. Natural product reports (Print), 2005

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The Traditional Medicine and Modern Medicine from Natural Products (2016, background): “Subsequently, they have been successfully employed in the discovery of new drugs and have exerted a far-reaching impact on chemicobiology [16–18].”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, background): “…Solanum spp. (Hsu and Tien, 1974; Liljegren, 1971) Curadermd (1989) Cancer chemotherapy (apoptosis triggering) Notes: a Resources: (Butler, 2005, 2008; Butler et al., 2014; Fürst and Zündorf, 2014; Newman and Cragg, 2012) and www.drugs.com. b Mixture of the two compounds. c…”
The exploration of macrocycles for drug discovery — an underexploited structural class (2008, background): “First, macrocyclic drugs have been predominantly discovered and applied as anti-infectives, and second, the rate at which novel macrocyclic scaffolds have entered clinical trials has dropped in parallel with the general decline in the use of natural-product extracts as discovery tool”