Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages1

By C. Godson, S. Mitchell, Killeen Harvey, N. Petasis, N. Hogg, H. Brady. Journal of Immunology, 2000

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Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. (2018, background): “This PMN phenotype switch marks the resolution phase, because lipoxin A 4 (LXA 4 ) also stimulates macrophage efferocytosis (phagocytosis of apoptotic PMNs and debris) (6, 7, 18, 19).”
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “They act on other immune cells through elaborating lipid mediators or may have autocrine effects on macrophages [142, 144].”
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation (2015, background): “In contrast to neutrophils, SPMs lead to macrophage shape changes that prepare the cells for phagocytosis of microorganisms, apoptotic cells and debris 9, 12, 62, 63 .”
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “LXA4 also stimulates nonphlo- gistic phagocytosis of apoptotic neutrophils, which accelerates the clearance of neutrophils and promotes resolution of inflammation (Godson et al., 2000).”