Electrical bioadhesive interface for bioelectronics
By Jue Deng, Hyunwoo Yuk, Jingjing Wu, Claudia E. Varela, Xiaoyu Chen, E. Roche, C. Guo, Xuanhe Zhao. Nature Materials, 2020
595 citations recorded by the source corpus.
Reliable functions of bioelectronic devices require conformal, stable and conductive interfaces with biological tissues. Integrating bioelectronic devices with tissues usually relies on physical attachment or surgical suturing; however, these methods face challenges such as non-conformal contact, unstable fixation, tissue damage, and/or scar formation. Here, we report an electrical bioadhesive (e-bioadhesive) interface, based on a thin layer of a graphene nanocomposite, that can provide rapid (adhesion formation within 5 s), robust (interfacial toughness >400 J m −2 ) and on-demand detachable integration of bioelectronic devices on diverse wet dynamic tissues. The electrical conductivity (>2.6 S m −1 ) of the e-bioadhesive interface further allows bidirectional bioelectronic communications. We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e-bioadhesive interface based on ex vivo porcine and in vivo rat models. These findings offer a promising strategy to improve tissue–device integration and enhance the performance of biointegrated electronic devices. A graphene nanocomposite hydrogel showing anisotropic swelling is used to realize an electrically conducting and removable bioadhesive that improves the mechanical and electrical integration of bioelectronics devices with wet dynamic tissues.
Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/aede8e2e63f6ac9855a849b02027d4226580c4fe
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In Biomedical Engineering
Citations in the corpus
- Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity (2021, background): “, conductive wearable/implantable devices.(66,67) Currently, there are two strategies for conductive hydrogels construction including electronic conduction via conductive filler (e.”
- Nanomedicine-Driven Modulation of the Gut–Brain Axis: Innovative Approaches to Managing Chronic Inflammation in Alzheimer’s and Parkinson’s Disease (2025, unknown): “New developments in flexible and implantable electronics have improved neuromuscular system stimulation and recording and have made neural implants more user-friendly with higher-quality signals [211,215,217,218].”