Preimplantation genetic testing for aneuploidy: are we examining the correct outcomes?
By J. Kemper, Rui Wang, D. Rolnik, Ben Willem J. Mol. 2020
20 citations recorded by the source corpus.
Questions continue to be raised regarding the benefit of genetic assessment of embryos prior to transfer in IVF, specifically with regards to preimplantation genetic testing for aneuploidy (PGT-A). To evaluate and quantify these concerns, we appraised the most recent (2012-2019) randomized controlled trials on the topic. Only two of these six studies listed cumulative live birth rates per started cycle, with both eliciting a statistically non-significant result. This article describes the concern that a focus on results from the first embryo transfer compared to cumulative outcomes falsely construes PGT-A as having superior outcomes, whilst its true benefit is not confirmed, and it cannot actually improve the true pregnancy outcome of an embryo pool.
Subfields: Infectious Diseases, Pediatrics, Perinatology and Child Health
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- M. Afnan
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- Abhishek Mishra
- Julian Savulescu
- Yanhe Liu
- Anthony David Jameson
Citations in the corpus
- Ethical Implementation of Artificial Intelligence to Select Embryos in In Vitro Fertilization (2021, background): “Examples of other developments to select embryos more likely to implant include (1) allowing embryos to self-deselect via extended culture in the laboratory [6], (2) metabolomic profiling of spent culture media [7] or (3) adding extra genetic testing such as pre-implantation genetic testing for aneu”