Biofilm formation mechanisms and targets for developing antibiofilm agents.
By Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu, H. Sintim. Future Medicinal Chemistry, 2015
643 citations recorded by the source corpus.
Biofilms are communities of microorganisms that are attached to a surface and play a significant role in the persistence of bacterial infections. Bacteria within a biofilm are several orders of magnitude more resistant to antibiotics, compared with planktonic bacteria. Thus far, no drugs are in clinical use that specifically target bacterial biofilms. This is probably because until recently the molecular details of biofilm formation were poorly understood. Bacteria integrate information from the environment, such as quorum-sensing autoinducers and nutrients, into appropriate biofilm-related gene expression, and the identity of the key players, such as cyclic dinucleotide second messengers and regulatory RNAs are beginning to be uncovered. Herein, we highlight the current understanding of the processes that lead to biofilm formation in many bacteria.
Subfields: Endocrinology, Health, Toxicology and Mutagenesis, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/aec6801f936409662cd24cbd598f06cbfe38a387
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology
In Health, Toxicology and Mutagenesis
In Molecular Biology
Citations in the corpus
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies (2021, background): “Flagella and type IV pili-mediated motilities are important for interactions between microorganisms and surfaces, and cell–cell aggregations to form microcolonies, respectively [28].”
- Marine Biofilms: A Successful Microbial Strategy With Economic Implications (2018, background): “Since then, both mechanisms involved in biofilm formation and methods to demote and prevent biofilms have been widely studied (see e.g., Donlan, 2001; de Carvalho and de Fonseca, 2007; Landini, 2009; de Carvalho, 2012b; de la Fuente-Núñez et al., 2012; Gu et al., 2013; Rabin et al., 2015).”