Cadmium inhibits the electron transfer chain and induces reactive oxygen species.

By Yudong Wang, Jing Fang, S. Leonard, Kevin Rao. Free Radical Biology & Medicine, 2004

707 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Heavy metal poisoning: the effects of cadmium on the kidney (2010, background): “Cd2? accumulates in mitochondria and inhibits the respiratory chain (and electron transfer) by acting at the level of complex III (Wang et al. 2004).”
Role of oxidative stress in cadmium toxicity and carcinogenesis (2009, positive): “Cd-generated radicals can also be detected with the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) in cultured cells (Yang et al., 2007), in isolated mitochondria (Wang et al., 2004), or in the cell-free system in the presence of metallothionein (O’Brien and Salacinski, 1998).”
Cadmium stress: an oxidative challenge (2010, positive): “Cd-induced ROS generation in mitochondria (Wang et al. 2004).”
Manganese-excess induces oxidative stress, lowers the pool of antioxidants and elevates activities of key antioxidative enzymes in rice seedlings (2011, result): “Similar results showing increased production of ROS due to toxicity of various metals have been shown in many crop species (Wang et al. 2004; Shi et al. 2005; Maheshwari and Dubey 2009; Sandalio et al. 2009).”
Effect of Heavy Metals on Fishes: Toxicity and Bioaccumulation (2021, background): “It inhibits the electron transfer chain in mitochondria and stimulates Reactive Oxygen Species (ROS) production [36].”