Pheromone binding by polymorphic mouse major urinary proteins

By Scott D. Sharrow, J. Vaughn, L. Žídek, M. Novotny, M. Stone. 2002

119 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. C. Mucignat-Caretta
2. M. Redaelli
3. A. Cavaggioni
4. Jane Hurst

In Nutrition and Dietetics

1. Jane Hurst
2. K. C. Persaud

In Sensory Systems

1. Jane Hurst
2. C. Mucignat-Caretta
3. M. Redaelli
4. A. Cavaggioni
5. K. C. Persaud

Citations in the corpus

• Airborne molecules released from male mouse urine affect female exploratory behavior (2014, background): “They are excreted in the urine of adult mice and are characterized by a wide range of isoforms (Cavaggioni and Mucignat-Caretta, 2000), some of which are specific for either sex and may transmit information regarding individual identity (Sharrow et al., 2002; Armstrong et al., 2005).”
• Differential binding between volatile ligands and major urinary proteins due to genetic variation in mice. (2012, unknown): “[50] isolated a MUP isoform present in nasal mucus as well as in the VNO of mice, and speculated that nasal MUPs may sequester volatile pheromone ligands and potentially transport them to their olfactory receptors.”
• Major Urinary Proteins on Nanodiamond-Based Resonators Toward Artificial Olfaction (2016, background): “However, the differences between isoforms are determined by small differences in the aminoacid sequence [11].”
• Thermodynamic consequences of disrupting a water‐mediated hydrogen bond network in a protein:pheromone complex (2005, methodology): “The pheromones SBT and HMH and the SBT analogs 2-n-propyl4,5-dihydrothiazole (n-PT) and MT were synthesized as described (Sharrow et al. 2002).”
• Mice recognize recent urine scent marks by the molecular composition. (2008, background): “…urinary protein complex (MUP), binds and hence concentrates scent molecules in urine and slowly releases them into the air, thus prolonging the lifetime of the scent (Bacchini et al. 1991; Böcskei et al. 1992; Robertson et al. 1996; Jemiolo et al. 2002; Sharrow et al. 2002; Armstrong et al. 2005).”
• Biology and Diseases of Mice (2015, unknown): “LABORATORY ANIMAL MEDICINE these elements, providing a 'bar code' that distinguishes individuals. Inbreeding of laboratory mice has reduced individual variation, but each inbred strain possesses a characteristic array of signals, and to a certain extent, unique signals exist among individuals within”
• Major urinary protein (MUP) profiles show dynamic changes rather than individual ‘barcode’ signatures (2015, background): “Keywords: major urinary proteins, barcode hypothesis, individual recognition, intra-individual consistency, inter-individual variation, Mus musculus musculus”
• High resolution X‐ray structures of mouse major urinary protein nasal isoform in complex with pheromones (2010, methodology): “Interestingly, SBT binds to MUP-IV about 20 times more tightly than to any of the five most abundant group 1 isoforms.(20) The first X-ray crystal structure of MUP(21) confirmed that the mouse MUP belong to the lipocalin superfamily.”
• The Structure, Stability and Pheromone Binding of the Male Mouse Protein Sex Pheromone Darcin (2014, background): “These unusual thermodynamics that are characteristic of the hydrophobic interactions between MUPs and pheromones are welldocumented and classified as ‘‘non-classical’’ hydrophobic interactions, unlike the classical ones which have favourable entropic contributions to the binding [52,55–59].”
• Individual recognition by scent (2004, background): “This cavity is flexible and is able to accommodate a wide range of small molecules including environmentally derived chemicals (Robertson et al. 1998), reporter molecules (Marie et al. 2001) and a variety of specific pheromones (Novonty et al. 1999, Sharrow et al. 2002).”