Frequency of TERT promoter mutations in human cancers
By J. Vinagre, Ana Almeida, Helena Pópulo, R. Batista, Joana Lyra, V. Pinto, R. Coelho, R. Celestino, H. Prazeres, L. Lima and 14 more. Nature Communications, 2013
850 citations recorded by the source corpus.
Subfields: Molecular Biology, Ophthalmology, Physiology
View Paper: https://www.semanticscholar.org/paper/ae0a41237a109f817ecf6a6cbdac917426f348e5
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In Molecular Biology
Citations in the corpus
- Landscape of somatic mutations in 560 breast cancer whole genome sequences (2016, neutral): “Common inherited variants conferring susceptibility to human disease are generally in non-coding regulatory regions and the possibility that similar mechanisms operate somatically in cancer was highlighted by the discovery of somatic driver substitutions in the TERT gene promoter22,23.”
- Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. (2015, background): “In addition, the panel contains probes that capture a 100-bp region in the TERT promoter where two recurrently mutated positions create de novo ETS transcription factor binding sites in melanoma,(23) thyroid,(24) gliomas,(25) and other cancers.(26) The panel contains probes that tile the positions o”