High-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex

By Nancy Milanesio, Leslie A. King, Yanshu Wang, J. Nathans, M. Tessier-Lavigne, Y. Zou. 2003

245 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. (2009, background): “Among cortical areas explored in different species, the barrel cortex is unique in offering a precise anatomical definition for a cortical column with clear functional correlates in the underlying synaptic circuits (Bureau et al., 2004, 2006; Feldmeyer et al., 1999, 2002; Petersen and Sakmann, 2000,”
Spike-Timing Dependence of Structural Plasticity Explains Cooperative Synapse Formation in the Neocortex (2012, background): “Quantal EPSC analysis in the adult neocortex showed that close to all synaptic contacts of the connection L4–L23 are functional [55].”
Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits (2005, background): “In this case, however, we are looking at direct unitary connections between pairs of neurons rather than individual synapses, and such direct connections between nearby cortical neurons are typically comprised of multiple individual synapses [6,21,34,42].”
Reconstruction and Simulation of Neocortical Microcircuitry. (2015, methodology): “We therefore modified the probability of release, consistent with experimental data for the specific sensitivities of different s-types to changes in [Ca]o (Gupta et al., 2000; Rozov et al., 2001; Silver et al., 2003; Tsodyks and Markram, 1997) (Figure S11; see Experimental Procedures).”
Synaptic energy use and supply. (2012, unknown): “…for cortical pyramidal to interneuron synapses (Deuchars and Thomson, 1995), 4–6 for spiny stellate and pyramidal cell to pyramidal cell synapses in cortex (Markram et al., 1997; Silver et al., 2003), and 6 for excitatory synapses onto pyramidal cells in hippocampal area CA1 (Larkman et al., 1997).”
Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. (2009, background): “Most connections between two cells in the cortex are relatively weak (Galarreta and Hestrin, 1998; but see Silver et al., 2003) and so a presynaptic neuron's spike produces a spike in its postsynaptic partners only rarely (Ts'o et al., 1986).”
Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. (2007, methodology): “Identification of synaptic contacts by light microscopy with biocytin staining has been used in previous studies of this kind and verified with electron microscopy (Lübke et al., 2000; Markram et al., 1997; Silver et al., 2003; Tamas et al., 1997, 1998, 2004; Wang et al., 2002).”
Homeostatic matching and nonlinear amplification at identified central synapses. (2008, unknown): “Indeed, many excitatory synapses in the mammalian brain can release at most one vesicle (Biro et al., 2005; Sargent et al., 2005; Silver et al., 2003).”
Single Spine Ca2+ Signals Evoked by Coincident EPSPs and Backpropagating Action Potentials in Spiny Stellate Cells of Layer 4 in the Juvenile Rat Somatosensory Barrel Cortex (2004, background): “Stellate neurons constitute the major recipient neurons for thalamocortical input and are thought to amplify and then relay excitation via their axonal arbor to other cortical layers, mostly restricted to within a barrel column (Feldmeyer et al., 1999, 2002; Lübke et al., 2000; Petersen and Sakmann,”