Effect of oversulfation on the chemical and biological properties of fucoidan

By X. Qiu, Ananda Amarasekara, V. Doctor. 2006

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Polysaccharides composition from tropical brown seaweeds (2012, background): “It has been noted that an increase in the sulfate content of fucoidan enhances biological activity (Qiu et al. 2006); however, sulfate group position, as well as molecular weights, monosaccharide composition, and their conformations are all believed to influence fucoidan biological activity (Li et…”
Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds (2011, unknown): “Since then, several investigations have focused on the effect of oversulfation of FCSPs on biological activity [54,78,84–89].”
Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae (2011, background): “51) and galactosidases [96,103] to target glycosidic bonds while preserving the sulfate groups [100].”