Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool
By P. Reddy, Lian Liu, Deepak Adhikari, K. Jagarlamudi, Singareddy Rajareddy, Yan Shen, C. Du, Wenli Tang, T. Hämäläinen, S. Peng and 4 more. Science, 2008
817 citations recorded by the source corpus.
Subfields: Molecular Biology, Public Health, Environmental and Occupational Health, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/ad528e4fd58c5d6c7402daaeb5241afdf896bd6b
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In Molecular Biology
In Public Health, Environmental and Occupational Health
In Reproductive Medicine
Citations in the corpus
- Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “Recent data in the mouse show that selective activation of the K-ras pathway in the oocyte results in rapid follicular development and depletion (75).”
- Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment (2013, background): “Studies using phosphatase and tensin homolog deleted from chromosome 10 (PTEN) deletion mice indicated the stimulatory roles of Akt signaling in the development of primordial (12) and secondary follicles (13).”
- The mammalian ovary from genesis to revelation. (2009, background): “Concurrent loss of Pten and Foxo3 in oocytes does not have a synergistic effect on follicle activation (178), and the PI3K inhibitor LY294002 suppresses primordial follicle activation in ovaries with Pten-deficient oocytes but has no effect in Foxo3 mutant ovaries (177), suggesting a linear PTEN-PI3”