Environment dominates over host genetics in shaping human gut microbiota
By Daphna Rothschild, O. Weissbrod, Elad Barkan, A. Kurilshikov, T. Korem, D. Zeevi, P. Costea, A. Godneva, I. Kalka, N. Bar and 19 more. Nature, 2018
2,408 citations recorded by the source corpus.
Subfields: General Health Professions, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/ad497d6aa1dfcae07f4f441ce26c0b0af9cb14dd
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In General Health Professions
In Molecular Biology
- E. Sonnenburg
- Justin L. Sonnenburg
- Tong Chen
- Eran Segal
- Meiping Lu
- Xubo Qian
- Zahraa Al Bander
- Tim D. Spector
Citations in the corpus
- The Gut Microbiota and Inflammation: An Overview (2020, background): “It should also be noted that existing findings lend to the idea that the composition of the human gut microbiota is influenced mainly by non-genetic factors [57].”
- Gut Microbiota-Targeted Diets Modulate Human Immune Status (2020, positive): “Diet has emerged as a driving factor in microbiota composition and function (Flint et al., 2017; Muegge et al., 2011; Rothschild et al., 2018; Zhernakova et al., 2016).”
- A practical guide to amplicon and metagenomic analysis of microbiome data (2020, background): “In human microbiome studies, the major differences in microbiome composition among individuals are due to factors such as diet, lifestyle, and drug use, such that the heritability is less than 2% (Rothschild et al., 2018).”
- Human gut microbiota/microbiome in health and diseases: a review (2020, background): “…creation of different antimicrobial substances, enhancing the immune system (Mills et al. 2019), playing a vital role in digestion and metabolism (Rothschild et al. 2018), controlling epithelial cell proliferation and differentiation (Wiley et al. 2017), modifying insulin resistance and…”
- Axes of a revolution: challenges and promises of big data in healthcare (2020, background): “…questions, such as the inter-person variability in post-meal glucose responses 55 , the ability to predict human traits from microbiome data, factors that shape the composition of the microbiome 56 , and associations between microbial genomic structural variants and host disease risk factors 57 .”
- Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “Where genetic factors play a limited role in shaping the microbiota composition [102], environmental factors, which include the short-term effect of fecal transplantation [103] and the more stable effects of dietary habits [94], are potent tools in this respect.”