Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses.

By E. Nobusawa, T. Aoyama, H. Kato, Yasuo Suzuki, Y. Tateno, K. Nakajima. 1991

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Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells (2008, methodology): “Based on this analysis the antigenic region recognized by CR6261 and CR6323 appears to segregate with a previously characterized division of HA’s that contains, H1, H2, H5, H6, H8, H9, H11, H12, H13 and H16 subtypes [36].”
Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes (2016, background): “Genetically, there are 16 influenza A subtypes of HA, which form two structurally and antigenically distinct groups (Nobusawa et al., 1991; Russell et al., 2004).”
A perspective on the structural and functional constraints for immune evasion: insights from the influenza virus (2017, background): “While a large portion of HA1 amino-acid sequence is highly variable [22] and is intrinsically tolerable to mutations, the receptor-binding site (RBS) is an exception [29, 30].”