Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.
By P. Flood-Page, A. Menzies-Gow, A. Kay, D. Robinson. American Journal of Respiratory and Critical Care Medicine, 2003
824 citations recorded by the source corpus.
Subfields: Immunology and Allergy, Physiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/acd7f60c127a659acc392f281de73a4a1a09e246
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In Immunology and Allergy
In Physiology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- T-helper type 2-driven inflammation defines major subphenotypes of asthma. (2009, background): “Residual IL-13 activity may therefore explain the incomplete tissue depletion of eosinophils observed in previous clinical trials of IL-5 blockade in asthma (37, 38).”
- The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “However, mepolizumab does not completely eliminate eosinophils from the airways, which may explain why it provides no clinical benefit (18).”
- A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. (2007, methodology): “A bronchoscopy study using a regimen of three doses given monthly, similar to this study, demonstrated that treatment with mepolizumab reduced airway mucosal eosinophil numbers by 55% in contrast to the 85% or more reduction in blood and sputum eosinophils seen in this and other studies ( 20 ).”
- Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. (2003, background): “As previously reported (30), there was a significant decrease in the number of bronchial mucosal eosinophils in asthmatics treated with anti–IL-5 antibody (mepolizumab) compared with placebo (P = 0.”
- Eosinophils: Biological Properties and Role in Health and Disease (2008, background): “The temporal association between increased inflammatory cell infiltration and increased AHR at 24 hours after allergen challenge in dual responders (Brusasco et al. 1990; Flood-Page et al. 2003b; Dorman et al. 2004a) has led to the suggestion of a causal relationship between the two.”