IFNα activates dormant haematopoietic stem cells in vivo

By M. Essers, Sandra Offner, W. Blanco-Bose, Z. Waibler, U. Kalinke, M. Duchosal, A. Trumpp. Nature, 2009

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Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “HSCs are multipotent progenitor cells that give rise to all types of mature blood cells [114], and are defined by their ability to self-renew and support long-term multi-lineage hematopoietic engraftment in lethally irradiatedmice [115,116].”
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. (2015, neutral): “A similar role of interferon signaling has been previously reported for hematopoietic stem cells where an acute treatment with interferon-a triggers proliferation of dormant HSCs (Essers et al., 2009).”
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production (2014, neutral): “HSC Expansion in Caspase-9-Deficient Mice Is Caused by Type I Interferons Type I IFNs have been shown to induce HSC proliferation, leading to functional exhaustion in vivo (Essers et al., 2009; Sato et al., 2009).”