Tuberculosis and diabetes mellitus: convergence of two epidemics

By K. Dooley, R. Chaisson. Lancet. Infectious Diseases (Print), 2009

933 citations recorded by the source corpus.

The link between diabetes mellitus and tuberculosis has been recognised for centuries. In recent decades, tuberculosis incidence has declined in high-income countries, but incidence remains high in countries that have high rates of infection with HIV, high prevalence of malnutrition and crowded living conditions, or poor tuberculosis control infrastructure. At the same time, diabetes mellitus prevalence is soaring globally, fuelled by obesity. There is growing evidence that diabetes mellitus is an important risk factor for tuberculosis and might affect disease presentation and treatment response. Furthermore, tuberculosis might induce glucose intolerance and worsen glycaemic control in people with diabetes. We review the epidemiology of the tuberculosis and diabetes epidemics, and provide a synopsis of the evidence for the role of diabetes mellitus in susceptibility to, clinical presentation of, and response to treatment for tuberculosis. In addition, we review potential mechanisms by which diabetes mellitus can cause tuberculosis, the effects of tuberculosis on diabetic control, and pharmacokinetic issues related to the co-management of diabetes and tuberculosis.

Subfields: Epidemiology, Infectious Diseases, Surgery

View Paper: https://www.semanticscholar.org/paper/abcc80af1584f7ac06c29f4dcf068b2b9e14ef35

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Citations in the corpus

• The impact of diabetes on tuberculosis treatment outcomes: A systematic review (2011, neutral): “Among patients afflicted with both TB and DM, diabetes is reported to be associated with poor TB treatment outcomes [7,11,12]; however, a systematic analysis to both clarify and quantify the association between DM and TB outcomes, including persistence of sputum culture positivity, failure, death an”
• Diabetes in Sub Saharan Africa 1999-2011: Epidemiology and public health implications. a systematic review (2011, background): “Unfortunately, proper epidemiological studies of the diabetestuberculosis association from Africa are to our knowledge missing [100].”
• Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis (2016, background): “25 Furthermore, metabolic disorders impair macrophage and lymphocyte functions with a subsequent status of reduced immune response, 26 which may render individuals more susceptible to infectious disease complications.”
• Infections in patients with diabetes mellitus: A review of pathogenesis (2012, background): “Many mechanisms have been proposed to explain the increased susceptibility to periodontal disease in these patients, such as alterations in immune response, subgingival microbiota aspects, altered collagen metabolism, alteration in oral vascularization, hereditary patterns, altered neutrophil functi”
• Risk Factors for Tuberculosis (2013, background): “A reverse association where TB can induce glucose intolerance and deteriorate glycaemic control in subjects with diabetes has also been identified [101].”