Sex-based differences in the effect of digoxin for the treatment of heart failure.

By S. Rathore, Yongfei Wang, Harlan M. Krumholz. New England Journal of Medicine, 2002

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Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. (2016, background): “Mortality under digitalis treatment was higher in women than in men in a post hoc analysis of the largest randomized prospective trial on digitalis in HF.145 Underlying reasons are unclear but may be associated with higher blood concentrations in women due to hormonal factors or sex differences in r”