Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

By S. Hirota, A. Ohashi, T. Nishida, K. Isozaki, K. Kinoshita, Y. Shinomura, Y. Kitamura. Gastroenterology, 2003

683 citations recorded by the source corpus.

Subfields: Gastroenterology, Hematology

View Paper: https://www.semanticscholar.org/paper/aae23b94d50f2be08873b2dd6e6774cbd259353d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. Christopher Corless
2. M. Heinrich

In Hematology

1. M. Heinrich
2. Christopher Corless

Citations in the corpus

• The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. (2004, background): “A: GIST with mutation in KIT shows positive in situ hybridization for KIT and DOG1 but not PDGFRA.”
• Gastrointestinal stromal tumours: origin and molecular oncology (2011, background): “Consistent with their extensive functional overlap, KIT and PDGFRA mutations are mutually exclusive in GIST”
• Role of platelet-derived growth factors in physiology and medicine. (2008, neutral): “In a subset of GISTs with wild-type Kit, gain-of-function mutations in PDGFR-A have been detected (Heinrich et al. 2003; Hirota et al. 2003).”