Osteoarthritis

By T. Vincent, Fiona Watt. The Lancet, 2015

1,092 citations recorded by the source corpus.

Osteoarthritis is a major source of pain, disability, and socioeconomic cost worldwide. The epidemiology of the disorder is complex and multifactorial, with genetic, biological, and biomechanical components. Aetiological factors are also joint specific. Joint replacement is an effective treatment for symptomatic end-stage disease, although functional outcomes can be poor and the lifespan of prostheses is limited. Consequently, the focus is shifting to disease prevention and the treatment of early osteoarthritis. This task is challenging since conventional imaging techniques can detect only quite advanced disease and the relation between pain and structural degeneration is not close. Nevertheless, advances in both imaging and biochemical markers offer potential for diagnosis and as outcome measures for new treatments. Joint-preserving interventions under development include lifestyle modification and pharmaceutical and surgical modalities. Some show potential, but at present few have proven ability to arrest or delay disease progression.

Subfields: Biomedical Engineering, Rheumatology, Surgery

View Paper: https://www.semanticscholar.org/paper/aad6e6e32ed0a9ee9603cc59303db7d89b7cd60c

Citations in the corpus

• Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies (2020, neutral): “Many researchers have shifted their focus to the prevention and treatment in the early stage of the disease [4].”