HMDD v2.0: a database for experimentally supported human microRNA and disease associations

By Chengxiang Qiu, Jian Tu, B. Geng, Jichun Yang, T. Jiang, Qinghua Cui. Nucleic Acids Res., 2013

820 citations recorded by the source corpus.

The Human microRNA Disease Database (HMDD; available via the Web site at http://cmbi.bjmu.edu.cn/hmdd and http://202.38.126.151/hmdd/tools/hmdd2.html) is a collection of experimentally supported human microRNA (miRNA) and disease associations. Here, we describe the HMDD v2.0 update that presented several novel options for users to facilitate exploration of the data in the database. In the updated database, miRNA–disease association data were annotated in more details. For example, miRNA–disease association data from genetics, epigenetics, circulating miRNAs and miRNA–target interactions were integrated into the database. In addition, HMDD v2.0 presented more data that were generated based on concepts derived from the miRNA–disease association data, including disease spectrum width of miRNAs and miRNA spectrum width of human diseases. Moreover, we provided users a link to download all the data in the HMDD v2.0 and a link to submit novel data into the database. Meanwhile, we also maintained the old version of HMDD. By keeping data sets up-to-date, HMDD should continue to serve as a valuable resource for investigating the roles of miRNAs in human disease.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aabf0f919f607bc9fb130d8715bb4a6a3c06e97d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zhou Huang
2. Yuan Zhou
3. Juan Wang
4. Qinghua Cui
5. Zhan Tong
6. Xing Chen

In Molecular Biology

1. Zhou Huang
2. Yuan Zhou
3. Juan Wang
4. Qinghua Cui
5. Zhan Tong
6. Xing Chen

Citations in the corpus

• miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions (2017, positive): “In previous version, we integrated data from HMDD v2.”
• MicroRNAs and complex diseases: from experimental results to computational models (2019, neutral): “HMDD (http://www.cuilab.cn/hmdd) [172] HMDD is a database that collects experimentally supported evidence for miRNA–diseases associations.”
• TransmiR v2.0: an updated transcription factor-microRNA regulation database (2018, background): “0 database (25) and a link to miRBase database.”
• miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database (2019, methodology): “List of the databases that are integrated by miRTarBase Type Database name Gene and miRNA-specific databases miRBase (7), NCBI Entrez gene (29), NCBI RefSeq (30) SNP or mutation related databases SomamiR (22,31) miRNA–disease association Database HMDD (9,10) The regulation of miRNAs TransMir (19), m”
• miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database (2015, background): “HMDD (14) is a database that collects experimentally supported human microRNA and disease associations and integrates miRNA-disease association data from genetics, epigenetics, circulating miRNAs and MTIs. miRecords (15) contains manually curated, experimentally validated and predicted miRNA targets”
• HMDD v3.0: a database for experimentally supported human microRNA–disease associations (2018, methodology): “For this purpose, we built the first version of human microRNA disease database (HMDD) on December 2007 (6) and released the second version on June 2013 (7).”