Functional Regeneration Beyond the Glial Scar
By Jared M. Cregg, Marc A. DePaul, Angela R. Filous, B. Lang, A. Tran, J. Silver. Experimental Neurology, 2014
634 citations recorded by the source corpus.
Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and help to entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience
View Paper: https://www.semanticscholar.org/paper/aa7d36f74a4b475d995d59198899340ea036c269
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Developmental Neuroscience
Citations in the corpus
- Astrocytes: a central element in neurological diseases (2016, neutral): “after trauma [24, 25, 45, 125, 201, 246, 260].”
- Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms (2019, background): “Activated astrocytes play a leading role in the formation of the glial scar (267).”
- The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “The view of astrocyte biology following SCI and the appreciation of their polarity and plasticity especially in the presence of very small lesions or where core inflammation and pericyte/fibroblast proliferation are at a minimum have evolved dramatically (77, 350, 351).”
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “Conversely, activated astrocytes can aggravate inflammation by producing proinflammatory cytokines and active nitrogen and oxygen species (RNS, ROS) which interfere with synaptic germination and axonal growth [330, 331].”