Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies

By K. Anderson, Ingunn M. Stromnes, P. Greenberg. Cancer Cell, 2017

617 citations recorded by the source corpus.

T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor signaling drives T lymphocytes to a functionally exhausted state. Here we discuss how the tumor and its microenvironment influences T cell trafficking and function with a focus on melanoma, pancreatic and ovarian cancer, and discuss how scientific advances may help overcome these hurdles.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/aa22314304e1c353ff96031cd9a95f3eb72744d7

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Citations in the corpus

• Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment (2018, background): “In cancer patients, T cells present several dysfunctions, and current immunotherapy strategies aim mainly at relieving the brake of T cell suppression (1, 2).”