A role for the Adenomatous Polyposis Coli protein in chromosome segregation

By K. Kaplan, A. Burds, Jason R. Swedlow, S. Bekir, Peter K. Sorger, I. Näthke. Nature Cell Biology, 2001

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. (2004, background): “APC may also have a Wnt-independent role in cell migration and chromosomal stability (Näthke et al. 1996; Fodde et al. 2001; Kaplan et al. 2001).”
Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling (2001, background): “In addition, APC mutations may also be responsible at least in part for chromosomal instability in colon cancer cells (Fodde et al., 2001; Kaplan et al., 2001).”
APC, Signal transduction and genetic instability in colorectal cancer (2001, background): “cgi?Q=wnt%20not%20dkk*%20not%20fzd*%20not%20sfrp*%20not%20wrch-1%20not%20loc56998%20not%20ryk%20not%20wif-1%20not%20wisp*&ORG=Hs">WNT signal transduction pathway, to cell adhesion, migration and apoptosis, and chromosomal segregation at mitosi”
On the road to cancer: aneuploidy and the mitotic checkpoint (2005, background): “In colorectal cancers (∼90% of which show CIN), an important cause of aneuploidy might be mutations in APC”