Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

By C. Sørensen, R. Syljuåsen, J. Falck, Tine Schroeder, L. Rönnstrand, Kum Khanna, Bin-Bing S. Zhou, J. Bartek, J. Lukas. Cancer Cell, 2003

600 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a9f9e2a8ff7483292c3cd1b2185d3c787b9339fe

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In Cell Biology

1. J. Bartek

In Molecular Biology

1. Thomas Helleday
2. J. Bartek
3. Stephen P. Jackson
4. J. Lukas
5. Yves Pommier

Citations in the corpus

• The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (2005, background): “2 mM) or CPT (100 nM), and a statistically significant decrease of both the hydroxyurea- and CPT-induced homologous recombination was observed after co-treatment with the kinase inhibitors caffeine (5 mM), UCN-01 (100 nM) or the Chk1-specific CEP-3891 (500 nM”