Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

By D. Planas, D. Veyer, A. Baidaliuk, I. Staropoli, F. Guivel-Benhassine, M. M. Rajah, C. Planchais, F. Porrot, Nicolas Robillard, J. Puech and 19 more. Nature, 2021

2,000 citations recorded by the source corpus.

Subfields: Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/a92d8e9c2e24886137b820c163b6e5dcc05c8500

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Michael J. Hogan
2. W. Garcia-Beltran
3. N. Pardi
4. Evan C. Lam
5. Kerri J. St. Denis
6. Adam D Nitido
7. B. Hauser
8. J. Feldman

Citations in the corpus

• mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant (2021, result): “Neutralization of Delta variant pseudovirus was decreased relative to wild type for all subgroups ( Figure 2C ), as has been previously reported (Mlcochova et al., 2021; Planas et al., 2021).”
• mRNA Vaccines in the COVID-19 Pandemic and Beyond. (2021, background): “Of these variants, Beta is associated with the greatest resistance to neutralizing antibodies in convalescent and vaccine sera, while Delta is associated with modestly reduced neutralization and an extremely high rate of transmission (26, 85).”
• Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa (2022, neutral): “Finally, sera obtained from individuals after both one and two doses of the BNT162b2 (Pfizer) or ChAdOx1 (AstraZeneca) vaccines displayed lower neutralization of the Beta and Delta variants compared with non-VOCs and the Alpha VOC (9).”