Toward a consensus definition for COPD exacerbations.

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The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. (2008, background): “COPD exacerbations in clinical trials are usually defined by the need for additional treatment ( 23 ).”
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007, background): “An exacerbation of COPD is defined as ‘‘an event in the natural course of the disease characterized by a change in the patient’s baseline dyspnea, cough, and/or sputum that is beyond normal day-to-day variations, is acute in onset, and may warrant a change in regular medication in a patient with und”
Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. (2004, positive): “These reported exacerbations that received treatment are in keeping with another definition of exacerbations recently suggested ( 28 ).”
Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution (2023, neutral): “ренцировать от обострений и при их наличии проводить соответствующее лечение [128, 291, 398, 417].”