DNA secondary structures: stability and function of G-quadruplex structures

By Matthew L. Bochman, K. Paeschke, V. Zakian. Nature reviews genetics, 2012

1,340 citations recorded by the source corpus.

In addition to the canonical double helix, DNA can fold into various other inter- and intramolecular secondary structures. Although many such structures were long thought to be in vitro artefacts, bioinformatics demonstrates that DNA sequences capable of forming these structures are conserved throughout evolution, suggesting the existence of non-B-form DNA in vivo. In addition, genes whose products promote formation or resolution of these structures are found in diverse organisms, and a growing body of work suggests that the resolution of DNA secondary structures is critical for genome integrity. This Review focuses on emerging evidence relating to the characteristics of G-quadruplex structures and the possible influence of such structures on genomic stability and cellular processes, such as transcription.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a8e1bec4e48ea4e022ee15004eddca5e1c440d02

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In Molecular Biology

1. D. Rhodes
2. H. Lipps

Citations in the corpus

• G-quadruplexes and their regulatory roles in biology (2015, background): “However, the finding that a number of helicases that are known to unwind Gquadruplexs in vitro (such as the RecQ helicases WRN and BLM), localize to telomeres and are required for telomere integrity in vivo, provide strong circumstantial evidence for the existence of such structures at mammalian tel”