Directed evolution of biocatalysts.

By Frances H. Arnold, A. Volkov. 1999

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Thermophilic Adaptation of Proteins (2001, background): “The technology of in vitro evolution is expected to have a large impact on the development of industrial biocatalysts (Arnold and Volkov, 1999).”
Industrial biocatalysis today and tomorrow (2001, background): “Enzyme catalysis in organic solvents The rapid growth of biocatalysis is a direct result of research and development in two key technologies: protein engineering, including molecular evolutio”
Directed evolution of new catalytic activity using the α/β-barrel scaffold (2000, unknown): “There is considerable practical interest in new biocatalysts, with methods of accelerated or directed evolution being used increasingly in academic and industrial laboratories to modify and improve enzymes, which can then be used for the synthesis of chemicals and pharmaceuticals (for review see”
Consensus protein design (2016, methodology): “Directed evolution and informatics-based rational design are transforming the field of protein engineering (Arnold and Volkov, 1999; Jiang et al., 2008; Lutz, 2010; Brustad and Arnold, 2011; Bornscheuer et al., 2012; Joh et al., 2014; Woolfson et al., 2015).”