The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.

By M. Mattapallil, E. Wawrousek, C. Chan, Hui Zhao, Jayeeta Roychoudhury, T. Ferguson, R. Caspi. Investigative Ophthalmology and Visual Science, 2012

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Inflammation and its role in age-related macular degeneration (2016, background): “A number of association studies have been performed using double knock-out mice lacking both Cx3cr1 and Ccl2 genes [152–155, 163] but their findings have been questioned since many transgenic mice carry the rd8 (retinal degeneration 8) mutation in their Crb-1 (crumbs-like 1) gene that also results i”
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2016, neutral): “The C57BL/6N mouse strain has been reported to carry the rd8 mutation, a single nucleotide deletion in the Crb1 gene (Mattapallil et al., 2012).”