Systemic sclerosis: a prototypic multisystem fibrotic disorder.

By J. Varga, David J. Abraham. Journal of Clinical Investigation, 2007

1,157 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/a89a6668619da297f63eeace8f8da17a452fa330

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. B. Hinz
2. TA Wynn
3. T. Cox
4. J. Erler
5. O. De Wever
6. M. Mareel

In Pathology and Forensic Medicine

1. TA Wynn
2. B. Hinz
3. J. Erler
4. T. Cox

In Pulmonary and Respiratory Medicine

1. B. Hinz
2. TA Wynn
3. V. Thannickal
4. Nikolaos G. Frangogiannis

Citations in the corpus

• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. (2012, background): “The dermis, lung parenchyma, heart, gastrointestinal tract, tendons, and ligaments are prominently affected, with endocrine organs, such as the thyroid gland, occasionally affected.(51) Interestingly, neither the liver nor the central nervous system show significant fibrosis in scleroderma.”
• Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, background): “Fibroblasts experimentally explanted from fibrotic lungs or skin lesions of SSc patients have been shown to have a constitutively activated myofibroblast-like phenotype, further implicating this cell type as a principal cause of disease (Varga and Abraham, 2007).”
• Cellular and molecular mechanisms of fibrosis (2008, background): “In the case of systemic sclerosis, vascular changes are a prominent and early manifestation of the disease, with impaired angiogenesis leading to the progressive disappearance of blood vessels [28,29].”
• The myofibroblast matrix: implications for tissue repair and fibrosis (2013, neutral): “The contribution of myofibroblastsand their elaborated ECM to normal and pathologic tissue repair [3]has been well-studied in lung [4-6], liver [7-9], kidney [10,11], skeletal muscle [12], systemic sclerosis [13-15], heart [16-18], and the stromal reaction to tumours[19,20].”
• The myofibroblast: paradigm for a mechanically active cell. (2010, background): “scleroderma (Strehlow and Korn, 1998; Varga and Abraham, 2007) and in the palmar fibromatosis of Dupuytren’s disease (Tomasek”