Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death
By Sreenivasa Rao Kondapally Seshasai, S. Kaptoge, A. Thompson, E. di Angelantonio, Pei Gao, N. Sarwar, P. Whincup, Ken J Mukamal, Richard F. Gillum, Ingar Holme and 11 more. New England Journal of Medicine, 2011
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BACKGROUND The extent to which diabetes mellitus or hyperglycemia is related to risk of death from cancer or other nonvascular conditions is uncertain. METHODS We calculated hazard ratios for cause-specific death, according to baseline diabetes status or fasting glucose level, from individual-participant data on 123,205 deaths among 820,900 people in 97 prospective studies. RESULTS After adjustment for age, sex, smoking status, and body-mass index, hazard ratios among persons with diabetes as compared with persons without diabetes were as follows: 1.80 (95% confidence interval [CI], 1.71 to 1.90) for death from any cause, 1.25 (95% CI, 1.19 to 1.31) for death from cancer, 2.32 (95% CI, 2.11 to 2.56) for death from vascular causes, and 1.73 (95% CI, 1.62 to 1.85) for death from other causes. Diabetes (vs. no diabetes) was moderately associated with death from cancers of the liver, pancreas, ovary, colorectum, lung, bladder, and breast. Aside from cancer and vascular disease, diabetes (vs. no diabetes) was also associated with death from renal disease, liver disease, pneumonia and other infectious diseases, mental disorders, nonhepatic digestive diseases, external causes, intentional self-harm, nervous-system disorders, and chronic obstructive pulmonary disease. Hazard ratios were appreciably reduced after further adjustment for glycemia measures, but not after adjustment for systolic blood pressure, lipid levels, inflammation or renal markers. Fasting glucose levels exceeding 100 mg per deciliter (5.6 mmol per liter), but not levels of 70 to 100 mg per deciliter (3.9 to 5.6 mmol per liter), were associated with death. A 50-year-old with diabetes died, on average, 6 years earlier than a counterpart without diabetes, with about 40% of the difference in survival attributable to excess nonvascular deaths. CONCLUSIONS In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors. (Funded by the British Heart Foundation and others.)
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a89247dcde559e5839cef19b130059e2ad9abc75
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In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- Global trends in diabetes complications: a review of current evidence (2018, neutral): “An international meta-analysis of 97 prospective studies representing 820,900 individuals with diabetes and 123,205 deaths throughout North America and Europe found that diabetes was associated with an increased risk for mortality from several cancers (17– 116% increased risk, depending on the cance”
- Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome. (2015, neutral): “Mortality among patients with type 2 diabetes, although higher than in the general population, varies widely depending on cardiovascular and renal coexisting conditions.(31,32) The overall annualized mortality in our trial was on the higher end of the risk spectrum that has been observed in other cl”
- Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease. (2016, background): “6; 28 354 deaths).(89) This hazard appeared similar when IHD, ischemic stroke, and PAD deaths were considered separately.”
- Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications (2016, neutral): “56) of death from vascular causes.(115) However, rates”