The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila.

By Liz Perkins, Michelle Johnson, Michael Melnick, Norbert Perrimon. 1996

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Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila (2022, background): “CSW is generally considered as a positive regulator of Ras/MAPK signaling (Perkins et al., 1996).”
Spacing Effect: SHP2 Phosphatase Regulates Resting Intervals Between Learning Trials in Long-Term Memory Induction (2009, unknown): “The PTPN11 gene and its ortholog in fruit flies, corkscrew (csw), encode the evolutionarily conserved protein tyrosine phosphatase SHP2 (Freeman et al., 1992; Neel et al., 2003), which is recruited to many receptor tyrosine kinases upon activation and is generally a positive regulator of Ras/MAPK si”
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. (2002, background): “1998; Feng 1999); and are essential during development (Kozlowski et al. 1993; Tsui et al. 1993; Tang et al. 1995; Arrandale et al. 1996; Perkins et al. 1996; Saxton et al. 1997).”
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome (2001, background): “, and mutations in the Drosophila homolog corkscrew ( csw ) affect oogenesis as well as the development of the central nervous system, ventral ectodermal, tracheal and terminal structure”