Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression

By Shai Koussevitzky, Ajit Nott, Todd C. Mockler, Fangxin Hong, Gilberto Sachetto-Martins, M. Surpin, Jason Lim, R. Mittler, Joanne Chory. Science, 2007

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Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)–type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in Arabidopsis are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a871e3b2b81f9bd997b709c36aee87e39c305507

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Citations in the corpus

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