Outcome and prognostic markers in severe drug‐induced liver disease

By E. Björnsson, R. Olsson. Hepatology, 2005

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Drug‐induced acute liver failure: Results of a U.S. multicenter, prospective study (2010, background): “Within the broad spectrum of causative agents, antimicrobials dominate.(13,16,18,21) Isoniazid, as monotherapy or in combination, commonly causes hepatoxicity leading to liver transplantation,(17) followed by sulfur drugs, nitrofurantoin, other antibiotics, and antifungals.”
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases (2019, background): “(187,231,238,239) In accordance with “Hy’s law,” serum aminotransferase levels >3-fold ULN and total serum bilirubin level >2-fold ULN increase the risk of death or need for LT in 9%-12% of patients.(240-242) Satisfaction of criteria for Hy’s law supports the institution of glucocorticoid therapy.”