Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.

By E. Susaki, Kazuki Tainaka, Dimitri Perrin, Fumiaki Kishino, T. Tawara, Tomonobu M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, Shun Yamaguchi and 6 more. Cell, 2014

1,210 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a80658a08eda5c14ba00a3c827082762e8e9d757

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Citations in the corpus

Single-Cell Phenotyping within Transparent Intact Tissue Through Whole-Body Clearing (2014, methodology): “…made a clear contribution: hydrogel embedding to stabilize tissue structures (Chung et al., 2013), fluorescent protein-compatible clearing reagents (Susaki et al., 2014), and imaging approaches for large or challenging tissue samples (Becker et al., 2013; Tseng et al., 2009; Tomer et al., 2014).”
The Human Cell Atlas (2017, neutral): “…of scores of proteins at cellular or sub-cellular resolution (Angelo et al., 2014; Chen et al., 2015a; Giesen et al., 2014; Hama et al., 2011; Susaki et al., 2014; Yang et al., 2014); various aspects of chromatin state (Buenrostro et al., 2015; Cusanovich et al., 2015; Farlik et al., 2015;…”
Mapping of brain activity by automated volume analysis of immediate early genes (2016, positive): “Imaging IEG expression in the intact brain using the Arc-dVenus fluorescent reporter has been reported along the publication of the CUBIC method and its expanded protocol (Susaki et al., 2014; 2015).”
Clarifying Tissue Clearing (2015, positive): “Lightsheet microscopes utilizing these designs are optimal for cleared tissue imaging when the highest optical resolution is not essential (Dodt et al., 2007; Susaki et al., 2014; Tomer et al., 2014; Verveer et al., 2007).”
High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level (2016, positive): “Recently, the CUBIC technique 18 has been a notable break-through in counterstaining mouse brains.”
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. (2014, neutral): “Resource iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging”
Simple, scalable proteomic imaging for high-dimensional profiling of intact systems (2015, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Renier et al., 2014; Richardson & Lichtman, 2015; Susaki et al., 2014).”