Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury*

By P. Parsons, M. Eisner, B. Thompson, Michael A. Matthay, M. Ancukiewicz, Gordon R. Bernard, A. Wheeler. Critical Care Medicine, 2005

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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors (2020, background): “anical ventilation, organ dysfunctions, morbidity and mortality in lung diseases [23,24].”
The cytokine storm and COVID‐19 (2020, background): “Excessive local release of cytokines is considered to be the determinant of pathological alterations and the clinical manifestation of ARDS.32 Overall, the primary pathological manifes- tations in the lung tissue are viral cytopathic‐like changes, infiltration of inflammatory cells, and the presence”
The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment (2011, background): “Follow-up human studies have demonstrated that patients who are ventilated with lower tidal volumes and lower airway pressures had a reduction both (a) in plasma levels of interleukin (IL)-8, IL-6, and soluble TNF receptor 1 (53) and (b) in the number of neutrophils and inflammatory markers in the a”