A requirement for CARMA1 in TCR-induced NF-κB activation

By Dong-hai Wang, Y. You, Sara M. Case, L. McAllister-Lucas, Lin Wang, P. Distefano, G. Núñez, J. Bertin, Xin Lin. Nature Immunology, 2002

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Phosphorylation of the CARMA1 Linker Controls NF-κB Activation (2005, background): “CARMA1 expression is predominantly restricted to lymphoid cells and is required for T cell receptor (TCR)-induced NF-kB activation in cell lines (Gaide et al., 2002; Pomerantz and Baltimore, 2002; Wang et al., 2002).”
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation (2014, unknown): “6 (Wang et al., 2002), deficient in CARMA1 expression (Figure 7C).”
Jurkat T cells and development of the T-cell receptor signalling paradigm (2004, background): “A noteworthy example involved the selection of Jurkat somatic mutants with defects in TCR-mediated NF-κB activatio”
A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008, methodology): “HEK293 cell lines constitutively expressing Nod1-Flag and HA-Nod2 with NF-kB-dependent GFP reporter were generated by transfection of pMSCV-puro-Nod1-Flag and pMX2-puro-HA-Nod2, respectively, and NFkB-eGFP (Wang et al, 2002), followed by antibiotic selection.”
NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, background): “Interestingly, PKC-θ is recruited to the rafts upon TCR activation, along with Bcl-10, which interacts with the adapter protein CARMA1 which is constitutively located in T-cell rafts (Gaide et al., 2002; Wang et al., 2002).”