Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies.

By L. de Koning, A. Merchant, Janice Pogue, Sonia S Anand. European Heart Journal, 2007

1,095 citations recorded by the source corpus.

AIMS The objectives of this study were to determine the association of waist circumference (WC) and waist-to-hip ratio (WHR) with the risk of incident cardiovascular disease (CVD) events and to determine whether the strength of association of WC and WHR with CVD risk is different. METHODS AND RESULTS This meta-regression analysis used a search strategy of keywords and MeSH terms to identify prospective cohort studies and randomized clinical trials of CVD risk and abdominal obesity from the Medline, Embase, and Cochrane databases. Fifteen articles (n = 258 114 participants, 4355 CVD events) reporting CVD risk by categorical and continuous measures of WC and WHR were included. For a 1 cm increase in WC, the relative risk (RR) of a CVD event increased by 2% (95% CI: 1-3%) overall after adjusting for age, cohort year, or treatment. For a 0.01 U increase in WHR, the RR increased by 5% (95% CI: 4-7%). These results were consistent in men and women. Overall risk estimates comparing the extreme quantiles of each measure suggested that WHR was more strongly associated with CVD than that for WC (WHR: RR = 1.95, 95% CI: 1.55-2.44; WC: RR = 1.63, 95% CI: 1.31-2.04), although this difference was not significant. The strength of association for each measure was similar in men and women. CONCLUSION WHR and WC are significantly associated with the risk of incident CVD events. These simple measures of abdominal obesity should be incorporated into CVD risk assessments.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Surgery

View Paper: https://www.semanticscholar.org/paper/a745a558268a2004fd9a17f41a835a989f05a412

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. C. Bushnell
2. C. Iadecola
3. R. Huxley
4. M. Creager
5. S. Blair
6. Massimo F. Piepoli

In Endocrinology, Diabetes and Metabolism

1. C. Iadecola
2. R. Eckel
3. R. Huxley
4. M. Creager

In Surgery

1. C. Bushnell
2. R. Eckel
3. R. Huxley
4. M. Creager

Citations in the corpus

• Guidelines for the Primary Prevention of Stroke (2011, positive): “01 increase in waist-to-hip ratio, there is a 5% increase in risk of CVD.(268)”
• Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk—a review of the literature (2010, methodology): “Adapted from de Koning et al., (2007). BMI, WC and WHR as predictors of cardiovascular risk R Huxley et al”
• Mortality trends in the general population: the importance of cardiorespiratory fitness (2010, background): “…triglyceride level (in men), and fasting plasma glucose, respectively, and a 0.2-mmol/L (8mg/dL) increment in high-density lipoprotein cholesterol based on other studies (Coutinho et al., 1999; de Koning et al., 2007; Gordon et al., 1989; Hokanson and Austin, 1996; Lewington et al., 2002).”