Age-related changes in grey and white matter structure throughout adulthood
By A. Giorgio, L. Santelli, Valentina Tomassini, R. Bosnell, Stephen M. Smith, Nicola De Stefano, Heidi Johansen-Berg. NeuroImage, 2010
517 citations recorded by the source corpus.
Normal ageing is associated with gradual brain atrophy. Determining spatial and temporal patterns of change can help shed light on underlying mechanisms. Neuroimaging provides various measures of brain structure that can be used to assess such age-related change but studies to date have typically considered single imaging measures. Although there is consensus on the notion that brain structure deteriorates with age, evidence on the precise time course and spatial distribution of changes is mixed. We assessed grey matter (GM) and white matter (WM) structure in a group of 66 adults aged between 23 and 81. Multimodal imaging measures included voxel-based morphometry (VBM)-style analysis of GM and WM volume and diffusion tensor imaging (DTI) metrics of WM microstructure. We found widespread reductions in GM volume from middle age onwards but earlier reductions in GM were detected in frontal cortex. Widespread age-related deterioration in WM microstructure was detected from young adulthood onwards. WM decline was detected earlier and more sensitively using DTI-based measures of microstructure than using markers of WM volume derived from conventional T1-weighted imaging.
Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/a72e3acb80e021e85be488520f01309aef443493
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- Nikolaus Weiskopf
- Bogdan Draganski
- John Ashburner
- Richard S. J. Frackowiak
- Denis Le Bihan
- Chloe Hutton
- Heidi Johansen-Berg
- Ferath Kherif
In Radiology, Nuclear Medicine and Imaging
- Nikolaus Weiskopf
- Bogdan Draganski
- Richard S. J. Frackowiak
- Chloe Hutton
- Denis Le Bihan
- Heidi Johansen-Berg
- John Ashburner
- Di Guo
Citations in the corpus
- Diffusion MRI at 25: Exploring brain tissue structure and function (2012, background): “…al., 2006), white matter continues to show slowmaturation, particularly in prefrontal pathways, through adolescence (Barnea-Goraly et al., 2005; Ben Bashat et al., 2005; Giorgio et al., 2008, 2010b; Schmithorst et al., 2005) and even into early adulthood (Giorgio et al., 2008; Snook et al., 2005).”
- Conserved and variable architecture of human white matter connectivity (2011, unknown): “In particular, it has been suggested that anatomical connectivity is not completely hard-wired for an individual's lifetime, but instead changes appreciably with age (over long time scales) (Giorgio et al., 2010; Wozniak and Lim, 2006), during development (over intermediate time scales) (Bava et al.”
- Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ) (2011, methodology): “Tensor-derived measures of fractional anisotropy (FA, an index of fibre coherence) and mean diffusivity (MD) show both linear and non-linear dependence on age (Charlton et al., 2006; Giorgio et al., 2010a, 2010b; Salat et al., 2005a; Salat et al., 2005b).”
- Convolutional Neural Networks-Based MRI Image Analysis for the Alzheimer’s Disease Prediction From Mild Cognitive Impairment (2018, background): “Normal aging has atrophy effects similar with AD (Giorgio et al., 2010).”