Synthetic Nanoparticles for Vaccines and Immunotherapy

By D. Irvine, M. Hanson, K. Rakhra, T. Tokatlian. 2015

683 citations recorded by the source corpus.

National Institutes of Health (U.S.) (Grants AI111860, CA174795, CA172164, AI091693, and AI095109)

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Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus (2019, background): “Among several technologies explored in this context (reviewed in Gause et al., 2017; Irvine et al., 2015), self-assembling proteins are a powerful platform for multivalent antigen presentation (López-Sagaseta et al.”
Self-assembling protein nanoparticles in the design of vaccines (2015, neutral): “As a minor note, synthetic nanoparticles made from non-polypeptide polymers, metals, or other solid supports, and the use of encapsulating particles as vaccine delivery systems are beyond the scope of the current review, and the reader is directed to alternative sources [31 – 33].”
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “Endosomal vesicles also play critical roles in innate and adaptive immunity as they are important sites for tolllike receptors and major histocompatibility complexes [37,38].”