Islet beta cell failure in type 2 diabetes.

By M. Prentki, Christopher J. Nolan. Journal of Clinical Investigation, 2006

1,606 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/a6f14c61f3fa0483fa8464ee04d8fc82f841548c

How researchers see this paper

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In Genetics

1. Rongbin Zhou
2. J. Tschopp

In Surgery

1. J. Tschopp

Citations in the corpus

• Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, neutral): “Leptin also potently inhibits glucoincretin- or GLP-1-induced insulin secretion, which augments GSIS through activation of the cAMP signaling pathways [252, 262].”
• Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013, background): “Proinflammatory cytokines, such as TNF-a and IL-1b, are significantly elevated in T2D (Herder et al., 2009; Spranger et al., 2003). u-3 FAs have been reported to enhance systemic insulin sensitivity via inhibition of TNF-a signaling pathway (Oh et al., 2010), however, some animal studies and several”
• The Pathophysiology of Gestational Diabetes Mellitus (2018, background): “Minor deficiencies in the β-cell machinery may only be exposed in times of metabolic stress, such as pregnancy [75].”