Wnt signaling in cancer
By T. Zhan, Niklas Rindtorff, Michael Boutros. 2016
1,748 citations recorded by the source corpus.
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
Subfields: Molecular Biology, Oncology
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In Molecular Biology
- Stephen B. Montgomery
- Matthew Stephens
- Eleazar Eskin
- Roderic Guigó
- Barbara E. Engelhardt
- Andrew Anand Brown
- Hae Kyung Im
- Emmanouil T. Dermitzakis
Citations in the corpus
- The impact of sex on gene expression across human tissues (2020, background): “CCDC88C is a negative regulator of the Wnt signaling pathway, a key mechanism in cancer progression (49), and the CCDC88C female ciseQTL signal in breast colocalizes with risk of breast cancer (Fig.”